NAD+

At a glance

• NAD+ is a coenzyme found in every living cell, central to converting the food you eat into the energy your cells run on
• Levels are lower in many older adults and under metabolic stress, which is the rationale for restoring them directly
• Delivered as an injection, a route that avoids the digestive breakdown that limits NAD+ taken as a pill
• Honest evidence status: the cell biology is Nobel-grade science; large human outcome trials are still early, and we say so
• Prescribed by a US-licensed physician, with medical supervision included for the length of your treatment

What it is

NAD+ (nicotinamide adenine dinucleotide) is not a drug in the usual sense. It is a molecule your body already makes and cannot live without: a coenzyme present in every cell, required for turning food into cellular energy, repairing DNA, and running the sirtuins, a family of proteins closely studied in aging research. Your NAD+ supply is not fixed. It is consumed continuously by these processes, and research has found lower levels in many older adults and in states of metabolic stress. NAD+ therapy supplies the molecule directly by injection, with the goal of restoring levels your cells can draw on.

How it works

Every demanding thing your body does, from a hard workout to an immune response to repairing damaged DNA, spends NAD+. The theory behind restoration is simple: keep the cellular energy currency topped up so the machinery that depends on it, mitochondria, repair enzymes, sirtuins, keeps running at full capacity. NAD+ taken as a pill is largely broken down in digestion, which is why the injection route exists: it delivers the molecule directly into circulation. Users most commonly pursue it for energy, mental clarity, and recovery.

What the research shows

We will give you the honest picture, because NAD+ is a field where marketing runs far ahead of data. The foundational science is exceptional: NAD+'s role in cellular energy and DNA repair is textbook biochemistry, and the aging biology around it is an active, serious research field. The human clinical evidence, however, is still early. A 2025 review in Nature Metabolism concluded that while preclinical studies are promising, human trials of NAD+ restoration have so far shown limited proven efficacy on hard health outcomes. What is well documented is that supplementation can raise NAD+ levels in the blood, and that treatment is well tolerated. What is not yet proven is that raising levels translates into measurable improvements in energy, aging, or disease for healthy adults. Many of our patients report feeling sharper and more energetic; we report that as experience, not as trial evidence.

What to expect

NAD+ therapy is typically used in ongoing cycles rather than as a one-time fix. Patients who respond usually describe changes in energy, focus, and recovery within the first weeks. Effects are individual, and because the outcome evidence is early, we encourage you to treat your own response as the test: if you do not notice a difference that matters to you, this may not be your tool, and your physician will say so rather than talk you into continuing. After checkout, a licensed physician reviews your intake before anything ships.

Side effects and who it's not for

NAD+ is generally well tolerated. Injection-site reactions are the most common issue; rapid intravenous administration elsewhere is known for transient flushing and nausea, which subcutaneous injection largely avoids. Because long-term human data are limited, we do not recommend it during pregnancy or with active cancer. Your physician screens for this during review.

FAQ