NR (Nicotinamide Riboside)

At a glance

• A form of vitamin B3 that your cells convert into NAD+, the coenzyme at the center of cellular energy production
• The best-studied NAD+ precursor in humans: clinical trials show it reliably raises blood NAD+ levels, typically by 40 to 60%. Those trials used oral NR; the compounded injectable form we offer has not been studied in the same way, and we say so.
• Clean safety record across trials, including at high doses
• Honest evidence status: raising NAD+ is proven; downstream health benefits in healthy adults are still being established
• Prescribed by a US-licensed physician, with medical supervision included for the length of your treatment

What it is

NR (nicotinamide riboside) is a specialized form of vitamin B3 and one of the most efficient building blocks your body has for making NAD+, the coenzyme every cell uses to produce energy and repair itself. Rather than supplying NAD+ directly, NR takes the precursor route: you provide the raw material, and your cells convert it through their own pathways. NR is the most clinically studied NAD+ precursor in humans, with multiple randomized trials behind it. Ours is a compounded injectable form, prepared by a licensed US compounding pharmacy and prescribed by a US-licensed physician.

How it works

Your cells cannot absorb much intact NAD+ from outside; they prefer to build it. NR enters cells readily and sits two enzymatic steps away from NAD+, making it an efficient feedstock. Trials consistently show that NR supplementation raises blood NAD+ levels, typically in the range of 40 to 60% at standard doses, within a couple of weeks. Those trials used oral NR; the compounded injectable form we offer has not been studied in the same way, and we say so. The logic is the same as for direct NAD+ therapy, restoring the cellular energy currency that daily life spends, but working with your body's own production line rather than around it.

What the research shows

NR has something rare in the longevity field: repeated, randomized human trials. They establish two things clearly. First, NR reliably raises NAD+ levels in blood. Second, it is well tolerated, including in a high-dose safety trial. What the trials have not yet established is that this translates into measurable improvements in performance, aging markers, or disease outcomes for healthy adults; results on those endpoints are early and mixed, and a 2025 Nature Metabolism review says exactly that. So our position is simple: NR demonstrably restores a molecule that matters, its safety record is strong, and the outcome science is still maturing. We would rather you buy it understanding that than believe a promise nobody can yet back.

What to expect

NR is unhurried by design. It restores a baseline rather than delivering an acute effect, so do not expect to feel a jolt on day one. Users who notice a difference typically describe steadier energy and better recovery emerging over several weeks of consistent use. It pairs naturally with training, sleep, and the rest of a longevity-focused routine. After checkout, a licensed physician reviews your intake before anything ships.

Side effects and who it's not for

NR has one of the cleanest safety records in this space. Across trials, side effects were mild and uncommon: occasional nausea, flushing, or headache. As with the rest of our longevity products, we do not recommend it during pregnancy or with active cancer, since NAD+ biology intersects with cell growth. Your physician screens for this during review.

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