

A prescription injection that combines multiple agents to open blood flow where it counts.
May help with:
Three medications in one dose (alprostadil, papaverine and phentolamine) that relax the blood vessels in the penis directly. Compounded by a U.S. state-licensed pharmacy. Not FDA-approved.
Two medications in one dose (papaverine and phentolamine) that relax the blood vessels in the penis directly. Compounded by a U.S. state-licensed pharmacy. Not FDA-approved.
A very small injection into the side of the penis, with a short, fine needle, 5 to 15 minutes before sex. Your clinician sets the dose and shows you how.
From $269 a month on the 3-month plan. Trimix and Bimix cost the same. No insurance needed.
Includes:
Often eligible for FSA/HSA reimbursement.



![]() | ![]() | Contains: | Two agents: papaverine, phentolamine | Three agents: alprostadil, papaverine, phentolamine | Works: | Within 5 to 15 minutes, often at a higher dose | Within 5 to 15 minutes, for most men at a low dose | Ideal for: | Men who get aching or burning from alprostadil | The strongest, most reliable response | Price: | From $269 a month | From $269 a month |
|---|---|---|
| Get startedUnsure? Start, decide later | Get startedUnsure? Start, decide later |

About your health and goals, in minutes.
Within 48 hours. Card held, not charged.
If prescribed, shipped within a few days.
Both relax the blood vessels directly. Trimix combines three agents and gives most men the strongest, most reliable response at a low dose. Bimix leaves out alprostadil, which suits men who get aching or burning from it, often at a higher dose. Same price; you pick at checkout.
Tablets first, for most people. The injection is for when tablets haven’t worked or don’t suit you. Your clinician makes that call with you.
It acts on the blood vessels directly, so it can start without arousal. Stimulation helps.
Early doses are often adjusted. Your clinician changes the dose with you; never change it on your own.
Ask your clinician. Many prescribe a reversal medication alongside the injection so you have it on hand.
Trimix and Bimix are compounded medications and are not FDA-approved. They are prescribed for erectile dysfunction when other treatments are not suitable. Use only the dose your clinician sets, and never more than once in 24 hours or more than three times a week. Do not inject within 24 hours of an ED tablet unless your clinician tells you to. Common side effects include pain or aching at the injection site or in the penis, bruising, and a small bump where the injection went in. Repeated injections in the same spot can cause scarring over time; rotate sites as your clinician shows you. An erection lasting more than 4 hours is a medical emergency: go to an emergency room. Do not use if you have sickle cell disease, a bleeding disorder, a history of priapism, or scarring or curvature of the penis. Tell your clinician about all medications you take. Store the vial refrigerated. This is not a complete list; your clinician will review risks with you.